I needed to run some windows only stats software on os x (WinBUGS/OpenBUGS).
The authors suggested running it in wine.
port install wine
That almost worked. MacPorts can't seem to deal with upgrades of anything at all, so I ended up getting rid of the macports directory and building everything from scratch.
Then, it worked. Really well.
I was surprised. I guess wine has got a lot better in the 10 years since I last tried to use it. And maybe this program was simple enough that it didn't trip on anything fancy.